Efficacy of Phage-Antibiotic Combinations Against Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates

Background: Increasing antibiotic resistance warrants therapeutic alternatives to eradicate resistant bacteria. Combined phage-antibiotic therapy is a promising approach for eliminating bacterial infections and limiting the evolution of therapy-resistant diseases. Objectives: In present study, we evaluated effects combinations bacteriophages antibiotics against multidrug-resistant (MDR) Klebsiella pneumoniae. Methods: Two MDR strains (GenBank no. MF953600 & MF953599) K. pneumoniae were used. Bacteriophages isolated from hospital sewage samples by employing double agar overlay assay identified transmission electron microscopy. For further characterization bacteriophages, killing host range test performed. To assess efficacy, phages (7.5 × 104 PFU/mL) used in combination with various antibiotics. Results: The phage-cefepime tetracycline displayed effects, restricting growth isolates, as evidenced recording OD650nm values. Conclusions: results current study showed that was potential treat caused